 COX 2 inhibitors may not be safer for the stomach
Nieuws van: British Medical Journal
Cyclo-oxygenase-2 inhibitors seem no better than conventional non-selective non-steroidal anti-inflammatory drugs in terms of the risk of an adverse upper gastrointestinal event. In a nested case-control study of more than 9000 cases of first peptic ulcer or haematemesis and almost 90 000 controls from 367 general practices throughout Great Britain, Hippisley-Cox and colleagues (p 1310) found that the risk of adverse events was increased with all NSAIDs included, selective and non-selective. Use of ulcer healing drugs reduced the increased risk of adverse events for all NSAIDs except diclofenac.
http://bmj.bmjjournals.com/cgi/content/full/331/7528/0-b - 3 Dec 2005
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